Negative staining is a sample analysis method which reveals particles’ gross structural details using a transmission electron microscope. It is an excellent method for providing a “quick-look” at your sample to evaluate its suitability for further analysis.
Our scientists have many years of experience using negative stain TEM methods.
We also offer optimized negative staining for more detailed assessments of sample behavior. When combined with 2D class averaging, and our single particle analysis (SPA) workflow, this provides insight into protein domain structure, antibody flexibility and sample integrity and morphology.
Types of Proteins We've Imaged
- Antibody-antigen complexes
- GPCRs
- Ion channels
- Membrane proteins
- Multi-component complexes
- PROTACs
- Molecular Glues
- Protein degraders
- Protein-nucleic acid complexes
- Proteins - with and without ligands
- Viruses
Samples We've Characterized
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